Tag Archives: logos

Knock Out Mouse Revolution

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Standing in the New Orleans convention center felt a little eerie. The interior was clean and neat. It looked like an airport. Still, I could not help but recall images of Katrina, when the huge edifice had become a beacon of false hope, luring the populace through its doors with the promise of aid, only to leave those who entered trapped like rats.

We had come to a conference to learn about endocrinology, which I had not considered too creepy before. I was wrong.

The proceedings began innocently. Hundreds of physician scientists, and I, filed quietly into a giant auditorium. I want to make clear my lack of qualifications relative to the rest of the group. I am no scientist, and barely a physician. I would much rather read philosophy books and climb around on crumbly sandstone towers than pipette solutions into a gel matrix.

But my job is mostly about helping people protect themselves from diabetes. Plus my wife had a poster to present. So, there I was, attending as an imposter.

The keynote speaker got a prolonged introduction. He deserved it. He was an important person with important research credentials. It was the kind of introduction where a name is never mentioned, for dramatic effect, and because everybody already knows exactly who the subject is. It is a an effective strategy for generating anticipation in the majority who are already quite familiar with the speaker, as well as in those who have never heard of him. It works for everyone, except my wife. She is honest to a fault, and that means that she is a real subject-object-verb kind of person. When presented with a dramatic, obscure speech, her attention lapses. As the speaker walked onstage to the sound of his name, she asked me who this Francis Collins person was.

After a long moment’s reflection, I told her that Francis Collins was a bad philosopher. She seemed to accept my summary, because she promptly settled back in her theater chair to nap through the rest of the lecture. I could not sleep, though I was feeling a little jet lag as well. The lecture was fascinating. Dr. Collins had been right in the middle of genetic research since the beginning of the human genome project, and he took the audience on a trip through the whole endeavor, right up to the current moment: the Big Data revolution.

The Big Data revolution referred to the use of advanced mathematical and computing techniques to sort through scads of data for druggable targets in endocrine diseases. The special techniques had become necessary because the database had exploded. Dr. Collins and his compatriots had deciphered the genomic book of life, but when they sat down to read it, they discovered that they needed a lamp, reading glasses, bookmarks, and indeed, the semantics of the language. The genes turned out to be active in the context of all sorts of transcription factors, promotors, coactivators, corepressors, etc. There was layer upon layer of conditionals which gave meaning to the genetics.

The source of the Big Data revelation was the knockout mouse. The knockout mouse and its cousins, the knockin mouse and the humanized mouse, were what happened when researchers turned to their traditional test subjects with gene manipulation techniques learned in dissecting the genome. By studying mice with selectively induced genetic defects, the researchers had produced the dense pile of data on gene regulation which advanced computing methods might sort out for us.

By the end of the keynote address, I had mouse fever. I wanted to hear all about the things which these creatures could do, and it turned out that I had come to the right place. Over the next few days, I would hear about mutant mice who could run on a treadmill off the couch like they had trained for months. Mice who developed diabetes. Mice who could turn on their brown fat to alter their metabolism. And many of these mice could serve as their own experimental controls. They had mechanisms inserted in their genomes which could turn their genetic defects on and off in response to substances in their mouse chow.

I’ll admit, when I heard about designer mice and their custom mouse chow, I got a little side-tracked. I had been eager to get out of medicine for a while. It all seemed so futile, and even a bit of a sham. Knockout mice might have been the ticket.

Two incidents elevated that thought to conscious consideration. The first was sighting a booth devoted to mouse chow in the exhibit hall.

To understand the significance of the chow booth, one must understand what the exhibit hall is all about. There is an exhibit hall at every conference. They are huge and opulent sometimes, sometimes modest, but always staffed by beautiful, shiny people and stocked with treats, from lattes to foam-model pancreases. Brands like Coach or Louis V. would feel at home amongst the booths.

Giant pharmaceutical companies ruled the hall, and the mouse kibble guys were right there in the mix. If mouse chow could buy an exhibit booth, the mice themselves must be golden.

The second incident was a conversation overheard in the poster hall.

The poster hall is a huge open space with row upon row of cork boards. Researchers pin up posters with summaries of their investigations on the boards, and attendees walk up and down the rows soaking in the knowledge. Usually there is a clearing in the middle with a nest of round banquet tables where everyone can go to take a break, chat and have a cup of pharma coffee. That’s where I sat while my wife presented her poster. I did not sit randomly.

As I walked up on the tables, I spotted a fat man in a plaid shirt and a yarmulke leaning in to say something to a thin, swarthy, bearded companion wearing a dark olive sport coat and a gold medallion. I needed in on that conversation, so I settled in the chair next to them, and swirled my coffee thoughtfully. Imagine my surprise as I picked up on the subject of their conspiracy.

“Yes,” said the fat man, ” I have been trying to find some of those mice. I need them to finish my work, but you can’t find them anywhere.”

“Yes,” echoed his friend, “those mice are nowhere to be found.”

“The closest I came,” the fat man continued, “was this Korean lady in San Fransisco. She said she had some, even said she would send me a few. But she never came through, and now I can’t get a hold of her anymore.”

The mice must be golden.

But my dreams of becoming a mouse Baron were short-lived. Upon further investigation, I found that genetically altered mice did not thrive. It was hard enough to get them past the embryonic stage. Once they could breathe on their own, they often required special conditions and diets just to survive. Worst of all, most of the really good mice had been patented. You bought the limited rights to a strain of mice when you bought the animals themselves. The patent system was the impetus for the black market discussion in the poster hall. You could trade for mice underground and avoid some costs, at the risk of incurring the wrath of the mouse factory lawyers after publication.

Despite the disappointment on economic grounds, I left the conference optimistic. I still had the image of all those colored bars from Dr. Collins’ slide in my head. Each one was a gene which a mouse model could exemplify, and therefore each one was potentially a druggable target. We had this. It was just a matter of time, and mice.

On my way to work, I have some time to think, though not too deeply. I leave early to beat the traffic, but I never do. Most commutes demand constant attention to collision avoidance. The situation is unfortunate, because the commute is the only time to think. Once work starts, I am behind. Someone constantly needs something from me to satisfy someone else who needs something from them, etc.. My workplace is carefully structured to facilitate this cycle. If I need to communicate with someone, odds are that I can lean over to one side and speak to them directly. Otherwise, my computer contains a messaging system which will pop in on whoever I need to inform or interrogate. Patient rooms cluster around my workstation, so I never need to walk more than 6 steps. However, patient contact occupies only a minor portion of my time. Most of the day is passed on the computer and the phone, addressing questions, requests and lab results. At the end of the day the freeway awaits again. By the time I get home, I am burned out and may or may not have it in me to do some physical training and watch television before retiring to get up and do it all again the next morning.

As luck would have it, traffic was light on the first day back from New Orleans. As I drove, I dreamed of druggable targets; Dr. Collins’ slides with the colored bars swam before me. Most of my patients were already on carefully targeted medications, but reaching down into the genome would ramp up medication effectiveness by orders of magnitude. Yet, not all my thoughts were so happy. Other images kept popping into my head, unbidden. I saw other colored slides, from another lecture by another renowned researcher. They were Dr. Brawley’s slides on the geographic and socioeconomic correlates of life expectancy and the epidemiology of conditions like obesity, cancer and diabetes. I could not banish those intrusive images, and by the time I was walking across the clinic parking lot, my mood had deteriorated.

I made it through the day, and finally got to resume my train of thought as I walked back to the car to drive home. I thought about gene targets and Dr. Brawley’s maps again. Then thoughts of one of the day’s patients joined the fray. She was very overweight, and had the metabolic problems that went with excess adipose tissue. She was on targeted therapy for her diabetes in the form of a monoclonal antibody directed at a counter-regulatory hormone receptor. It was the best science had to offer, but she often missed her doses. She had 2 jobs and no car, so she was up early and home late, and she simply forgot her meds sometimes. She set an alarm, but often could not attend to it, or forgot to reset it. We did not even discuss diet and exercise. She lived on a busy street with non-contiguous sidewalks, had no money for a gym, and no time to travel to a safe park. She could not cook, because she had grown up on packaged foods. In any case, she had grown too heavy by now. Her knees had given out under the weight. She could only mobilize fat stores in the face of severe calorie restriction. To reclaim  her life, assuming that was our aim, she would need two joint replacements and a gastric bypass.

I began to re-experience the rising panic which I had felt at the end of her appointment. Dr. Collins & Co. had let me down; I was not armed for this struggle, nor would I be. I stopped to take a breath and get my bearings. The parking lot was nearly empty. A bad smell rose from a nearby drainage grate, and a noise like water flowing.

I imagined that the noise might be something else. Maybe, instead of waste water, it was all those knockout mice, rising through the  sewers from the depths of the New Orleans convention center where the disappointments of Katrina had flowed down to bring the little fellows back, like a time-delayed Ghost Dance. The mice were coming with their little spectral incisors primed to clip down the cages, the labs, the chow booth, the convention center, and all the rest in a massive, surgical revision. I became convinced that the sound was the mice coming. It had to be. It was the only way that the knockout mice could save us.

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Balance Impaired

 

DSC00176Close-up, the little gully evoked a strong sense of deja vu. The angle suggested that one might almost be able to stand up and walk it. The rock looked like a crocodile’s skin – all knobs and chunks with few cracks or pockets – and the few voids in the surface had formed from the erosion of yellow clay inclusions. I had been in this situation before, in the Canadian Rockies, the Tetons, the Cascades. It meant sparse and dubious protection for insecure climbing, with an ugly fall looming throughout.

The fresh memory of yesterday’s Eureka foray reinforced my unease. Just going into the mining country in Colorado’s San Juan mountains is sobering.  The road winds through acres of avalanche terrain peppered with jumbles of gray boards and rusty iron marking the eternal resting places of generations of abandoned avarice. Eureka itself stands for self-consciousness of our bitter relationship with the range. Once a small,  hopeful mining community the town is now a single building. The lone, windowless watchtower bears a prominent sign with the name of the town, placed there, no doubt, by the same sort of joker who might strap a party hat on a skeleton.

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Yesterday was our second consecutive day at the ice climbs in the valley above the ghost town. The day before, we had been denied access to the longest climb in the area by an SAR exercise. Yesterday, we encountered a line of four parties on the same route, and we decided to trudge a bit further past the routes at the valley’s entrance. Around the bend and not far above, we found a lovely pillar of ice baking in the sun. The air temperature was cold however, and the ice looked to be in good shape from the ground, so we went for it.

My partner took the lead and ran the two pitches together. It went well until the very top. There he found the last few feet melted out and he could not get to the fixed anchor. Worse, in a fit of hubris, neither of us had thought to have him take the kit for building ice anchors. He put in two ice screws at his high point and I lowered him back to an intermediate ledge. He set up a belay and I set off to retrieve the ice screws and build an anchor in the ice to get us back down to the base.

Looking up at the situation, I knew that I should not risk falling. He had placed the two screws at the anchor properly. They had already held his weight on the lower. But the stainless steel tubes were basking. Many times, I had raced the process now at work on the anchor, placing another screw on a sunny climb before the last one heated up enough to melt loose. I arrived at the anchor and placed a back-up screw. Out of curiosity, I jiggled the anchor screws. They rattled in their holes, and by the time finished the rappel anchor, I could lift the screws free with two fingers.

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By the time we got back down, the crowds had migrated our way. We had another objective in mind for the afternoon, but our hopes were squashed on the road, for we found a fellow standing at the head of the approach trail just staring across the valley as if he were reconsidering something. He informed us that he had ridden a slab avalanche for a few meters down the slope below our goal.  My partner had his wife and young son waiting back in Ouray anyhow.

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There had been angst around bringing the child, who was their first. He was a nidus of concern in some familiar ways. He was 18 months old and did not want to eat or sleep regularly. He clearly understood everything said to him, but his only bit of expressive language was the word “No”. Each morning, he spent a non-stop hour on Rube-Goldberg action. Cups went into other cups, packets of jelly were transferred from person to person and then into the cups, and then back to their original owner. All of this chaos worried his parents. It seemed so overwhelming that one could hardly imagine any organized behavior arising from it.

Unless you had seen it before. I had. I distinctly recalled worrying about how I could possibly teach my first child to speak. I had no training, and no idea where to begin. Nevertheless, the kid started to talk. He had inherited the talent for it. From an adult perspective, it looked like a miracle, because adults liked to think that they had, each and every one, invented the world – or at worst discovered it. That way, the adult felt more competent, and the world seemed more solid.

From the child’s standpoint, he was building a constellation from the inside out. He had his experiences – what he might come to call ‘sense impressions’ should he grow into a particularly deluded adult – and he had the dots and lines to mark and tie together those experiences, inherited in his nucleic acids, language, and culture. The dots and lines were powerful tools. They would allow him to develop at heady pace, mapping out massive territories, like language, on the fly.

His ancestral mechanisms  assembled his star chart in a blur, and if he was at all self-conscious in his adulthood, he would spend a lot of time figuring out how he got there, and what kind of picture he had made with all those dots and lines overlying the bright spots of his experience. It would be daunting and he might be tempted to throw his hands up and just call the dots and lines the truth, to give the mathematical, linguistic and philosophical accretions on experience an undeserved solidity, while relegating the experience itself to a dirtier, incomplete status.

My partner’s son would have an antidote in that case. He would learn to climb, and that would at least open the blinds on the relationship between the picture of the stars and the stars themselves. He would still have to look, but most people didn’t even get that chance.

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Perched in the little gully, I saw the true landscape.

I was not motivated. I felt the burden of all those extraneous considerations which populated the slope with angels and demons instead of little edges and blotches of ice. I climbed back down and handed the sharp end over to my partner. He was motivated, and managed to lead the pitch despite some misgivings about the security of the climbing. I followed without slips or fumbles. It was sketchy, no question. We looked at the next pitch, but decided against it. It would be there when the stars aligned favorably, or even better, when no one was thinking about the pattern of stars at their back.

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The Problem with Pain

My gaze swung between the man on the exam table and the radiograph displayed on the lightbox. He must have sensed a problem.

“What?” he asked.

What indeed. The film basically showed his shoulder blade broken in two.

“When did this happen?” I inquired. He had already told me once; I just needed to be sure that I’d heard it correctly.

“Yesterday afternoon,” he said, ” right after lunch.”

“And why did you wait until this afternoon to come in?’

“Well, I’m here mostly to get my wife off my back. If it was up to me, I wouldn’t have come in, but she thought it might be serious or something, because I tossed and turned last night.”

“Well,” I told him, “It is not a surgical problem, but it is a bad injury. You got lucky.”

After a moment’s reflection I added, “Didn’t that hurt?”

“Kind of,” he laughed, “But it eased up pretty quick.”

“Do you need any pain medication?” I asked.

“Oh, no,” he demurred, “Tylenol is doing fine for it.”

After a few more pleasantries, the man got up, walked out of my office, got in his car and drove back to work. Watching him wince slightly as he turned out of the parking lot, I couldn’t help but think of the patient before him – a fellow with no history of serious injury, a normal MRI of the lumbar spine, and disabling back pain.

The man with the back pain had wanted pain medication. I’d had to talk him out of it, which was a difficult task in that era. Because it was the era before the opioid crisis, when we were in the midst of a pain crisis, according to the medical authorities. Clinicians were directed to take everyone’s pain level the same way that we took their temperature, and to treat the abnormalities discovered by our measurements.

For those with eyes to see, the notion behind pathologizing pain was misguided, at least. The whole scheme rested on the idea that pain was simply activity in the neuronal substrate. Change the activity pattern, by activating opiate receptors, for example, and you get rid of the pain.

I am not being very charitable in my description, but I am being as charitable as I need to be. There are more nuanced depictions, which leaven the mix with talk of psychological context and so on, but the same suppressed premise lurks beneath them all. It is this: a chain of causal events ‘add up’ to pain, and that is just what pain is. X+Y+Z = Pain. But the necessity of such arithmetic has been in doubt even before Hume laid its troubles out so nicely for us Westerners.

Breaking down a phenomenon gives you its pieces, but does not grant commutativity. Activating opiate receptors does not reshape their owner’s pain experience according to a fixed script. Receptor activity is part of the description of a painful experience, along with psychological context, and personal history. Yet there is no prior necessity – necessity by law, rather than necessity in fact. We did not make the distinction.

Secure in our estimation of the relationship between the neuronal substrate and the pain experience, we went after opiate receptors like we go after splinters. Our efforts did not force anyone’s pain experience into a box, but we gave everyone who we treated a new pain experience. Sometimes it suited them better; sometimes it suited them worse. Many, many times it settled in the center of their psyches and they fell into orbit around it.

Our engagement with the epidemic of untreated pain predictably ended in chaos. Now we need to extricate ourselves, and what do we turn to but the tool already in hand.

Instead of the reduction to type, we have rebuilt our story of pain, revising our reduction on the basis of the same mistake. Receptors pertain to behaviors – in the neuronal substrate, and so in the psychology, and so in the organism – but pain is a byproduct of the behavioral mechanism. It is an epiphenomenon. Chronic experiencers need counselling, to convince them that the pain is ineffectual, and therefore not real, at least not in any serious way.

Unfortunately, I get to participate in this second shot at commutative reduction, too. It will go just as well as the first.

 

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The One Brute Fact

Even naming a brute fact, a Brute Fact, is the beginning of a mistake, but it can’t be helped.

Before I open my eyes, I am groping toward a mood. Some say that my mood will be nonintentional – that it will not be about something.

I disagree.

My mood will not have content, but it will stand in relation to something, in this case my unawareness at first, and then my time and place, and then where I left off before sleep. This ‘standing in relation’ – orientation in it’s most basic sense – is everything.

It is the bone of intention – the ‘aboutness’ itself, rather than the analysis of an intentional relation. It comes with consciousness and is not really distinguishable from consciousness. Logic (and its mathematical adjunct) models it, by permission.

Immediately, it yields identity and explanatory reduction. Further out, it leads to categories and theories. All this is natural to us, and renders meaningless terms like ‘supernatural’ and ‘separate mental substance’.

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A Quick Defense of Fideism

First, consider the alternative: natural theology. It is a failure on two levels. On a technical basis, all the arguments which constitute natural theology rest upon a claim that God can be known in the same way that we know any subject of our experience. No matter how clever the argument, the basic  premise saddles a natural deity with some very limiting baggage – like an appointment book of times and places where the deity must be, with the associated activities and relationships. And, if the deity is the sort of fellow who can have an appointment book, then It is not the sort of fellow who can have all the limitless characteristics(?) which make a deity interesting.

Which leads to the level two problem: the arguments of natural theology lead to a deity who is completely uninteresting. Let’s say that someone came up with a cosmological argument which made sense, for instance. God is left with some familiar questions. It can’t tell anything about the source of Its motive by examining It’s creative act. It can’t say why It woke on our day #1 with the thought of creation in Its mind, any more than I can say why I looked at the ceiling fan when I opened my eyes this morning*. We are left with a God who is a guy. It’s a very powerful guy, but one who is in the same metaphysical boat as we are.

Two arguments are typically advanced to remedy the above situation. Let’s call them the Springboard argument and the Aspect argument. In the Springboard, we creep to the edge of an explanatory plank (think Aquinas’ contingency argument) and then launch to a conclusion by inference. For instance, the conclusion that, because we can’t abide an infinite regress of contingent causes, there must be a non-contingent cause at the source of causation.

In the Aspect argument, we are told that we may discover aspects of the deity by analysis of our experience, but that we should not expect to see Its whole structure due to our own limitations, though that structure is implied in the aspects.

The trouble is, neither of these arguments offer any explanation of what is in their remainders – the unexplained parts. In the Springboard, the remainders are things like an explanation of non-contingent causality. In the Aspect, the remainders are relations between things like intentionality and aseity or omnipresence. In other words, there is no account, in either the Springboard or the Aspect arguments, of the things lost in the guy-God conclusions of natural theology.

Implications are fine, but in the end, we need to be able to say what is implied, or we have gotten nowhere. Both the Springboard and the Aspect fail to give such an account, and we can see in their shared mode of failure, that they are actually the same argument. To understand an aspect of something which is unlimited and fully extant, is to understand nothing about “it”. To leap into an inexplicable conclusion, is to leap into the void.

But we are faced with voids no matter which way we turn. There are situations where we can’t climb out of our own skins (to borrow a phrase from Dr. Blackburn) to look into our own motives or the intelligibility of our experience. In those cases, no beliefs are possible, but assertions are as good as a shrug and a shake of the head.

So, if you feel that there must be something rather than nothing, nothing is stopping you. There.


*I can give a reductive explanation for what motivated me to look at the ceiling fan, but then I must explain my motive for reducing and explaining, and so on and so on…the motives seem to come first.

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‘Cause You’re Doin’ it Wrong

Regarding thoughts and discussion of deity, the question must eventually arise, ” Why?”. Once one has decided not to take such notions too seriously, why engage on the matter with those who do?

Morbid curiosity is part of the answer. Or to paraphrase a famous psychologist’s response to the same question about his interest in UFO’s: I am more interested in the motives for holding the belief, than I am in the belief itself.

But beyond morbid curiosity, there is an ethical impetus. For within the mish-mash of desperate apology and cognitive dissonance, lies a kernel of consistency. It begins with the question, “Why is there something rather than nothing?”

It is a ridiculous question, but the reason why it is ridiculous is interesting. We are in the world and can never step outside to see whether the world must be as it is, what other way it might be, or whether it must be at all. In light of our blindness on the matter, an assertion of existential necessity appears to need no further justification. And that’s good, because nothing explains (existential necessity) God, though (existential necessity) God explains everything  – if you believe it. And that’s as far as it goes, for those few who are ethically sound.

For the rest, they go on to endow existential necessity with intentionality, motive and any number of other, inconsistent properties, all as a way of swinging their dicks around  (to allay their own anxieties, most often). That is doing it wrong, and I just hate to see folks doing it wrong.

 

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Why Have Children?

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Everyone who has had children has asked themselves the question. The answers leave one feeling a bit squeamish, because the answers are all tautologies. The simplest is some version of: Because people have children. The more complicated responses – to make little caretakers for ourselves, for example – beg the question off to another, underlying tautology (We want to live because we live, in this case). There is no immediately obvious rationale.

The question in question is just the sort of question which religion purports to answer. But answers from divine purpose fare no better than circumstantial answers. The simplest answer from religion is: Because God commands it, which does not differ functionally from the first statement above, ‘Because people have children’. More nuanced responses again beg off to deeper tautologies, like the famed divine mission statement from the Christians: Man’s chief end is to glorify God and enjoy Him forever. The statement is lovely, but it is devoid of functional content. After thorough contemplation, we are still left standing around, awaiting the Lord’s instructions before we can get on with the glorifying and enjoying.

These tautologies lurk at the bottom of all teleology. No attempts to divine purpose from conditions avoid the fate of Leibniz’s theodicy. When applied, teleological excursions all discover the type of gem unearthed by Dr. Pangloss.  Study of a language’s syntax alone, will never reveal the language’s semantics. What is cannot tell us why it is, any more than it can tell us what ought to be. Attempts to divine purpose from structure, while operating strictly within the structure, are futile.

So, why have children? Why not? Or more precisely, why ask why? It is not a fit question.

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Buddy the Blastocyst’s Ensoulment Adventure

It’s the wildest yarn of them all. Be warned: you may not like the ending, but the thrill is worth it.

Let’s set the scene.

In the lead role, we have Buddy. He consists of a few hundred cells arranged in a hollow sphere. There is nothing too special about Buddy. He is not that far removed from the fused gametes which preceded him in that he is full of promise, yet without much substance or even a distinguishing feature. To be honest, he is a pretty passive character in his own tale.

As such, he is a perfect foil for the soul. The soul is no simpleton, and unlike Buddy, the soul is very difficult  to describe. Here we can turn to words from the wise philosophers and theologians who have previously contemplated the mystery of the soul. The wise have described the soul as the “I”-ness of experience or the proper subject of mental properties. The key point to take from such descriptions is: Don’t ask the wise for directions to the nearest coffee shop. Those directions are likely to lack substance.

Substance is exactly what we need in the case of the soul, to characterize it. Lucky for us, we need no more than substance, or at least the agreement that the soul is a substance distinct from the sphere of cells which is Buddy. Not everybody will agree. Some may contend that Buddy is simply the dawning realization of something which has always been, kind of like a Chrysler LeBaron. Let me try to clarify.

In a certain sense, one could contend that the specific turbulence pattern in the early universe, doomed us to the Chrysler LeBaron, because one could ostensibly track a chain of distinct events back from the structure of the LeBaron to the details of the turbulence pattern of the early universe. And by the same token, one could track the turbulence pattern back to a purported state of affairs before the early universe started doing anything. A claim of pre-existing potential opens up, of which the early turbulence pattern and the Lebaron are mere manifestations.

There are loads of problems with this account of history, but only a couple concern Buddy and his soul. First, we cannot do anything with this account. An auto designer in 1896 could not foresee the Lebaron in all it’s hideous detail. We can see the inevitable  manifestation of LeBaron essence in retrospect only. Think vitalism (and its discontents).

Second, the pre-existing potentials do not do anything for themselves. They are manifested, without occupying space or expending energy or participating in the manifestation process, other than as an additional explanation. Like solipsism, the tale of essences suffers from terminal irrelevance.

Therefore, Buddy shall receive soul-stuff rather than a post-hoc rationalization.

Now, what is the nature of Buddy’s relationship to his soul, and how does the soul adhere to that little, hollow sphere of cells? Maybe the second question is too ambitious. Yet at least there has to be a singular moment in which some sort of threshold for ensoulment is surpassed and the membranes which a moment ago contained only chemical elements now serve as vesicles for spirit.

Some spirit-permeable membrane channel opens or an angel-beacon gene gets transcribed, and the soul binds to Buddy irrevocably. This must be the case. We want an active soul for Buddy, so he cannot merely slip into it. In that case – where Buddy is the realization of some soul formula written into the cosmos – we are right back to the maximally inefficient essences.

Once he has his soul, Buddy begins to exist in two worlds at once. He takes in nutrients, builds membranes, and generally engages with events in the world. At the same time, he is moved by the spirit to do Good or Evil, and his soul bears the weight of his activities in the world.

At the end of it all for Buddy, he can stand in the court of the Lord and the Lord can say to his angel, “Bring me Buddy and I shall judge him, for he lusted after a Unicorn Frappe and was moved by the wickedness in his soul to purchase a Unicorn Frappe, and his soul was soiled by the act. ”

“Wait, who is this you bring before me? No, no, that’s Benny, who turned aside from his evil impulses and purchased a tall coffee. Now let Benny go and bring me Buddy, who smells of shame and sugar, not wholesome ground roast.”

How else does the Lord know who is Benny and who is Buddy?

And so we have arrived at the shocking dénouement: the story of Buddy’s spiritual existence and his physical existence are one and the same. His soul, however convoluted the mechanism, moves electrons, as much as a magnet moves electrons. His soul, as much as any magnet, is moved by electrons. In being so engaged, Buddy’s soul becomes part of the reductive explanations which constitute physicality.

Is this the end for Buddy’s soul?

For his soul as a supernatural substance, maybe it is. But the point of the story is: those supernatural substances can’t get going in the first place.

They just don’t hold together at all.

For Buddy’s soul as a strange appendage, who knows?

The world is a weird place.

 

 

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The Word from the Land of Absolute Relativism

“Look at all this shit!”
He waved the stack of envelopes at me.
“Look at this one.”
He held up the letter on top. It was from another hospital and marked, ‘Important: Do Not Discard’.
“These are the ones you have to be careful to discard.”
He threw it in the wastebasket, and followed it with the rest of the unexamined mail. I was far enough into my training not to be shocked by this sort of thing. I’d weathered surgeon’s tirades and soaked up jaded, callous humor in the emergency room. Still, my experience with this psychiatrist had me believing for years afterwards that, in his specialty, like sought like.
“This kind of clutter is the enemy,” he continued, opening the top drawer in his desk.
He scooped out a handful of keys.
“Look at these! I don’t know what this is for,” he said, holding up a sturdy door key. Into the bin it went.
He tossed a few more, then dumped the remainder back in the drawer with an expression of disgust.
“We’ve wasted enough time,” he declared, “better show me the case.”
I handed him the chart, with my history on top. He lingered on the assessment at the bottom of the page. Residents sometimes began to sweat when attending physicians paused too long in their documentation review. I did not in this case, because the assessment was not mine in the first place; the patient brought her diagnosis with her from the last admission. He grunted and moved on to the ancillary notes, containing the comments from psychiatric nurses who had evaluated the patient.
“Jesus Christ! Did you read this?”
Now I began to sweat. I hadn’t read the nurse’s notes. He handed me the chart with a shake of his head. I’d gotten lucky; the question was rhetorical. Curiosity displaced my anxiety and I began to read with interest. Immediately, I realized what he was on about.
At the bottom of the page, several of the nurses (a cabal?) postulated that dark forces were at work in the patient’s life. The assessment dwelt upon the young lady’s practice of witchcraft, not as an expression of alienation in a personality dangerously adrift, but as an activity with sinister efficacy. I looked up at him as I finished reading.
“How can we hope to do anything for the patients when we’re up against this kind of stupidity from the staff? Borderline,” he stated, returning to my assessment, “Do you really believe that?”
I shrugged. She had the black nail-polish sign, which every trainee knew was pathognomonic for borderline personality disorder.
“There are some people that fit the bill, but mostly the term is an epithet applied to people who we don’t like because they are frustrating. It’s the DSM used as a cudgel, and it justifies our bringing these people into the institution when their community becomes too frustrated with their behaviors. They come in for a few days or a few weeks until they’ve cooled off, then they go back out with the same problems, to the same problems. So this kind of inpatient treatment is like firing into the tree line: it’s good for keeping the enemy’s head down, but it’s not good for hitting anything.”
His words were familiar in structure and reference. At home that evening, I poured through my memory and my boxes of books, and I eventually placed them. They recalled an image from Heart of Darkness.

Once, I remember, we came upon a man-of-war anchored off the coast. There wasn’t even a shed there, and she was shelling the bush. It appears the French had one of their wars going on thereabouts. Her ensign dropped limp like a rag; the muzzles of the long six-inch guns stuck out all over the low hull; the greasy, slimy swell swung her up lazily and let her down, swaying her thin masts. In the empty immensity of earth, sky and water, there she was, incomprehensible, firing into a continent. Pop, would go one of the six-inch guns; a small flame would dart and vanish, a little white smoke would disappear, a tiny projectile would give a feeble screech – and nothing happened. Nothing could happen. There was a touch of insanity in the proceeding, a sense of lugubrious drollery in the sight; and it was not dissipated by somebody on board assuring me earnestly there was a camp of natives – he called them enemies! – hidden out of sight somewhere.

The image stuck and grew stronger over the years until I ceased to see my preceptor as chief among madmen and came to see him as Marlow on the boat. He was the lone relativist in a wilderness of absolutists who considered borderline personality more than a label on a charge sheet (it is that at least, for the Diagnostic and Statistical Manual which codified the term is a tool intended to itemize mental illness for billing). For his fellow wardens of the institution, there existed a borderline personality fact about certain people, caused by borderline personality pathologies and amenable, potentially, to borderline personality treatments. He saw them firing into a continent. He did not, of course, live in the land of absolute relativism, where everything is an onion made of layer upon layer of motives and relations with no pertinent core. He believed in borderline personality as a country over yonder. It recognized certain commonalities, but those commonalities arose in the villages. They accrued; they did not come down from on high.
He cared about how seriously the nurses, psychologists and patients took diagnoses, not because relativism was true. He cared because absolutes did not obtain. Worse, absolutes destroyed. On occasion, bullets fired into the tree line did hit something, and that something was an enemy by definition. Over his career, he’d seen victory declared over schizophrenia and the state institutions emptied onto the street. He’d seen the profession take a pass on intractable diagnoses, like personality disorders. He’d heard from his predecessors about neurosurgical solutions considered quite successful in their time. It wasn’t that relativism was true, it was just that truth didn’t work that way. It wasn’t diagnosis-friendly, and the truth about psychology all the less so.

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